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The effect of oral analgesic premedication on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis: A randomized clinical trial

 Journal of Dental Materials 10.22038/jdmt.2024.71444.1571 Abstract Objective: This study aimed to evaluate the effect of different premedication protocols on the success rate of the inferior alveolar nerve block (IANB) technique in mandibular molars with irreversible pulpitis. Methods:  Two hundred and ten   participants were randomly assigned into three groups (n=70) and received one of the following premedications 30 minutes before IANB injection: dexamethasone, pharmapain (containing acetaminophen, ibuprofen, and caffeine), and a placebo lactose capsule. Pain severity was evaluated with the Heft–Parker visual analog scale (VAS) before and 15 minutes after the injection, during dentin removal, and when inserting files into the root canal. The IANB injection was considered successful if VAS values after 15 minutes implied no pain or mild pain. Results:   IANB success rates were comparable in the dexamethasone (51.4%), pharmapain (55.7%), and

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